Inhibition of Furine Nucleotide Metabolism by 6-Methylthiopurine Ribonucleoside and Structurally Related Compounds1
نویسندگان
چکیده
6-Methylthiopurine ribonucleoside was found to inhibit nucleotide formation from hypoxanthine and aminoimidazole carboxamide in Ehrlich ascites tumor cells in vitro and to inhibit inosinate dehydrogenase activity in intact cells. These effects are produced at higher drug concentrations than required to inhibit purine biosynthesis de novo. 4-Methylthio-7-|8-D-ribofuranosyl pyrrolo[2,3-i/]pyrimidine also inhibited nucleotide formation and inosinate dehydrogenase activity, and several other methylthio purine ribonucleoside analogs or derivatives also inhibited one or another of these processes.
منابع مشابه
Inhibition of Furine Ribonucleotide and Phosphoribosyl Pyrophosphate Synthesis by 6-CycIopentylthio-9- hydroxymethylpurine and Structurally Related Compounds1
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